top of page

Case Narrative

Mr NM is a 23 year old Indian factory worker had a chemical burn on his right thigh 8 days which became badly infected. On examination, he was febrile (38.5C) and flushed. Heart rate was 93/min and BP was 103/60 mm Hg. Liver and renal function was normal. He was started on a parenteral antibiotic, 500mg administered by slow intravenous infusion over 2 hours, every 8 hours.

Relevant Drug Information

The antibiotic has good activity against gram positive bacteria, particularly staphylococci. It is eliminated primarily by renal excretion. Generally, a trough plasma concentration of about 15-20mg/L would be considered effective against most Staph aureus infections that have an MIC of 1mg/L. Concentrations lower than 10 mg/L may however, predispose to development of bacterial resistance. It has been suggested that average concentrations above 25mg/L might be associated with increased risk of nephrotoxicity. An alternative therapeutic target is to maintain the AUC:MIC ratio above 400.

Show patient data
Back to first patient

Multiple Dose IV Infusion (Antibiotic)

Switch patient
Change population

Would you like to see all the 20 patients in the population?

To go back to single patient view, please click "​Back to first population" button, then click "Yes" button

interactive graphs.PNG

Click here to go to "Interactive Pharmacokinetic Graphs"

How would you like to optimize the dose and frequency?

Dose adjustment



Frequency Adjustment

Apply changes
bottom of page