PHARMACOKINETICS
Clinical Scenario Equations
The equations we use to generate the graphical outputs for the various scenarios are provided below.
Randomization
The population variability is generated by applying a log-normal distribution to the primary parameters with the standard deviation (SD) empirically set as 20% of the population mean. Patients are randomly generated according to this distribution. Although this amount of variability is empirical, we believe this is a conservative representation of what has been observed clinically for many drugs. (see References)
Remember, the idea here is only to aid in the visualization of potential degrees of variability. Consequently, these graphs should not to be used for clinical predictions. We therefore, do not explicitly name the drug, although it may be recognizably similar to commonly prescribed drugs in the market. This is after all just a learning tool, and not a predictive one!
