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Multiple Oral Dose (NSAID)

Mr TCK is a 30 Chinese man who has recently been diagnosed as having an inflammatory arthritis of unknown cause. While waiting to complete his diagnostic work-up, you have prescribed a non-steroidal anti-inflammatory drug, empirically named here T03, to relieve his painful right knee. Apart from his arthritis, he is clinically well and does not have evidence of liver or kidney disease.

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T03 is a newly licensed non-steroidal anti-inflammatory drug. The dose you chose is based on the standard dose recommended by the manufacturer, 75mg twice a day. It is a relatively well absorbed drug with an average bioavailability of about 90%. It is primarily cleared by hepatic metabolism, with no active metabolites. Its plasma elimination half-life is approximately 6-8 hours. Large scale clinical trials suggest that analgesic effects are on average observable at plasma concentrations exceeding 2.5mg/L, while anti-inflammatory effects require peak concentrations of at least 5mg/L. Plasma concentrations greater than 7mg/L may be associated with a higher risk of hepatoxicity.

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