PHARMACOKINETICS
Graph controls
Tau (Hr)
Dose ( 1 tablet = 175 mg)
Dose non-compliance
Time non-compliance
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Multiple Oral Dose (Compliance)
A 45 year old lady is being treated for a chest infection with a novel oral antibiotic, A063. The antibiotic is generally well absorbed, though with a variable bioavailability, and is eliminated primarily through hepatic metabolism. The reported elimination half-life is about 12 hours. Trough plasma concentrations exceeding 8mg/L is associated with good therapeutic outcomes and low risk of resistance development, whereas concentrations above 16mg/L may be associated with increasing risks of cardiotoxicity.
Case Narrative
Points to Consider
Failure to comply with medication orders is one of the most problematic and overlooked problems in therapeutics. In the idealized situation, as shown in this default graph, the steady state concentrations are pretty much where you want them to be. But this does not take into consideration the potential non-compliance issues.
Under Graph Controls in the right column you will see Non-Compliance settings for Dose and for Timing. Observe how changing the level of non-compliance affects the steady-state concentrations of the antibiotic. Consider how the varying degrees of non-compliance may impact upon your ability to control the infection without compromising on any risk of cardiotoxicity.