Multiple Oral Dose (Antiepileptic) - Non-linear
Would you like to see all the 20 patients in the population?
To go back to single patient view, please click "Back to first population" button, then click "Yes" button
Ms TP is young lady with complex psychomotor seizures. She was placed on an oral regiment of an anti-convulsant. Based on standard therapeutic recommendations, her starting dose was 200mg twice daily.
This drug has a half-life of about 10-22 hours but exhibits non-linear pharmacokinetics due largely to saturable drug metabolism.
Current evidence suggests that to achieve adequate suppression of seizures, the trough concentrations should be above 0.01 mg/mL. However, concentrations above 0.02 mg/mL may be associated with increasing risks of drowsiness, suicidal ideation, and possible risks of arrhythmias.
Relevant Drug Information